Bring a large pot of lightly salted water to a boil. Cook pasta in boiling water, stirring occasionally until still firm to the bite, about 9 minutes. Drain and set aside.
Preheat oven to 350°F. Butter a 9 x 13-inch baking dish.
Prepare the radicchio by cutting the head in half and removing the core. Thinly slice the leaves and set aside.
Heat olive oil in a large pot over medium heat. Add mushrooms, onion, salt, and pepper to taste. Cook and stir until mushrooms have browned and onion is translucent, about 7 minutes. Add radicchio, garlic, and sage; cook until radicchio has wilted, and garlic is fragrant, about 3 minutes. Remove from heat and stir in pasta. Set it aside.
Melt butter in a saucepan over medium-high heat. Whisk in flour; cook until foaming. Pour in milk, whisking constantly, until mixture comes to a boil and thickens, about 5 minutes. Remove from heat; whisk in Asiago cheese, heavy cream, 1 cup Parmesan cheese, ½ tsp salt and ¼ tsp black pepper until sauce is melted and smooth.
Pour sauce over pasta mixture; stir until thoroughly combined. Transfer to prepared baking dish. Combine the remining ½ cup Parmesan cheese with the panko breadcrumbs and spread evenly over the pasta mixture. Bake in the preheated oven until bubbly, about 30 minutes. If you wish, broil for about 1 minute or until the topping is golden brown.
